Everything You Should Know About Post Exposure Prophylaxis in Singapore

Everything You Should Know About Post Exposure Prophylaxis in Singapore

Post-Exposure Prophylaxis, or PEP, is a vital medical treatment that can prevent HIV infection after potential exposure. Whether the exposure occurred through unprotected sex, a broken condom, or accidental contact with infected blood, PEP provides a crucial safety net when administered quickly and correctly.

In Singapore, access to PEP is available through licensed clinics, hospitals, and emergency departments, ensuring timely medical intervention for those at risk. However, many people remain unaware of how PEP works, when it should be taken, and what to expect during treatment.

This guide explains everything you need to know about Post-Exposure Prophylaxis in Singapore—from how it works to eligibility, timelines, and follow-up care—so you can act confidently and protect your health when faced with a potential HIV exposure.

What Is Post-Exposure Prophylaxis (PEP)?

Post-Exposure Prophylaxis (PEP) refers to the use of antiretroviral medications taken after a possible exposure to HIV. These medications prevent the virus from establishing a permanent infection in the body.

PEP is not a vaccine or a cure. Instead, it acts as an emergency measure, blocking the virus’s ability to replicate during the early stages of exposure. When taken correctly within the recommended timeframe, PEP can reduce the risk of HIV transmission by more than 80–90%.

Doctors prescribe PEP in situations where an individual may have been exposed to HIV through:

• Unprotected sexual contact with an HIV-positive or unknown-status partner

• Condom breakage or slippage during sex

• Accidental exposure to infected blood (e.g., needlestick injuries in healthcare settings

• Sexual assault or rape involving potential HIV exposure

How PEP Works

HIV infection begins when the virus enters the bloodstream and starts replicating inside immune cells. PEP interferes with this process by introducing powerful antiretroviral drugs that block replication before the virus becomes established.

The treatment typically involves a combination of two to three medications, taken daily for 28 days. These drugs are the same types used in long-term HIV therapy but are prescribed for short-term preventive use.

The key factor in PEP’s success is timing—the earlier it’s started, the better it works.

When Should You Take PEP?

1. The 72-Hour Rule

PEP must be started within 72 hours (3 days) of potential HIV exposure. Every hour matters; effectiveness decreases with time. Ideally, treatment should begin within 2 to 24 hours after exposure.

If more than 72 hours have passed, PEP is generally no longer effective, and your doctor may discuss alternative testing and preventive strategies instead.

2. Situations That Require Immediate Medical Attention

Seek PEP as soon as possible if:

• You had unprotected sex with someone whose HIV status is positive or unknown.

• A condom broke during sex.

• You shared needles or syringes with others.

• You experienced a needlestick injury at work involving potential exposure.

• You were sexually assaulted and unsure about the assailant’s HIV status.

3. For Healthcare Workers

Healthcare professionals exposed to potentially infected blood or bodily fluids should report the incident immediately to their occupational health unit, where post-exposure management protocols, including PEP, are available.

Where to Get PEP in Singapore

PEP is available at major hospitals, sexual health clinics, and selected medical centers across Singapore. Some clinics offer 24-hour emergency access for urgent cases.

If exposure occurs during non-office hours, visit an emergency department immediately rather than waiting for a clinic to open. Medical staff can assess your risk and prescribe the appropriate medication on the spot.

When you visit, you’ll undergo a brief consultation to evaluate:

• The nature of exposure (sexual, occupational, or accidental)

• The time elapsed since exposure

• The HIV status of the source (if known)

• Any existing health conditions or medications you’re taking

This evaluation helps doctors determine whether PEP is necessary and which drug combination is most suitable for you.

The PEP Treatment Process

A doctor will assess your exposure risk through a confidential discussion. You’ll be asked about the time, type, and circumstances of the incident. Blood tests may be taken to establish your baseline HIV status and check liver and kidney function before treatment begins.

Step 2: Prescription

You’ll receive a prescription for a 28-day course of antiretroviral medication. The most common regimen includes a combination of Tenofovir, Emtricitabine, and Dolutegravir, though your doctor may adjust this based on availability and suitability.

Step 3: Starting Medication

PEP should be taken as soon as possible, ideally on the same day as exposure. Consistent adherence to the medication schedule is critical for effectiveness.

Step 4: Follow-Up Visits

Follow-up appointments are essential to monitor side effects and assess treatment response. You’ll also undergo repeat HIV tests at:

• 6 weeks

• 3 months

• 6 months after exposure

These confirm whether the treatment successfully prevented infection.

Common Side Effects of PEP

• PEP medications are generally well-tolerated, but mild side effects can occur, such as:

• Nausea or upset stomach

• Fatigue or headache

• Mild diarrhea

• Sleep disturbances

Most of these symptoms subside after a few days and can be managed with supportive care. If severe side effects develop, consult your doctor immediately—do not stop taking PEP without medical advice.

How Effective Is PEP?

When taken correctly and started promptly, PEP can reduce the risk of HIV infection by up to 90% or more. However, it is not 100% effective. Factors that influence its success include:

• Timing of initiation: Sooner is always better—starting within hours offers the best protection.

• Adherence to medication: Skipping doses can lower effectiveness.

• Type of exposure: Some forms of exposure carry higher viral loads and therefore greater risk.

• Overall health: Existing health conditions or immune suppression can impact outcomes.

Doctors emphasize that PEP is a one-time emergency measure, not a long-term prevention method.

PEP vs. PrEP: What’s the Difference?

While both PEP and PrEP involve antiretroviral medications, their purposes differ:

PEP (Post-Exposure Prophylaxis)	PrEP (Pre-Exposure Prophylaxis)
Taken after potential HIV exposure	Taken before potential exposure
Short-term (28 days)	Long-term, daily use
Emergency prevention	Ongoing prevention
Must start within 72 hours	Must be taken consistently

Individuals who frequently face potential HIV exposure—such as those with multiple partners or healthcare workers—may consider transitioning from PEP to PrEP for sustained protection.

Cost of PEP in Singapore

The cost of PEP varies depending on where you receive it and the type of medication prescribed. On average:

• Private clinics: SGD 900 – SGD 1,200 for a full 28-day course

• Public hospitals: May be lower, especially for citizens and permanent residents

Consultation fees, follow-up visits, and laboratory tests may be additional. Some insurance policies or workplace health schemes may partially cover these costs.

Emotional and Psychological Support

The anxiety that follows potential HIV exposure can be overwhelming. Many individuals experience fear, guilt, or stress while waiting for test results.

Healthcare providers in Singapore are trained to handle such cases sensitively. Counseling is available both during and after treatment to help patients cope emotionally and understand their options moving forward. Confidentiality is always maintained throughout the process.

Preventing Future HIV Exposure

After completing PEP, take preventive steps to reduce future risks:

• Use condoms consistently during sexual activity

• Avoid sharing needles or personal items that may contact blood

• Get tested regularly for HIV and other STDs

• Consider PrEP if you are at ongoing risk

• Discuss vaccination options for hepatitis B and HPV with your doctor

Education and awareness are key to breaking the cycle of fear and misinformation surrounding HIV.

Choose Little Cross Family Clinic and Anteh Dispensary for Your PEP Consultation in Singapore

If you believe you’ve been exposed to HIV, timely medical attention is crucial. Little Cross Family Clinic in Tampines and Anteh Dispensary Clinic in Geylang provide discreet, professional consultations and access to Post-Exposure Prophylaxis (PEP) within the vital 72-hour window.

With decades of combined family medical experience, the doctors at both clinics guide each patient through risk assessment, prescription, and follow-up testing in a confidential and supportive setting. Their patient-first approach ensures treatment begins quickly, supported by compassionate counseling and expert medical care during a stressful time.

Choosing trusted, MOH-approved clinics like Little Cross Family Clinic and Anteh Dispensary ensures your PEP care is handled promptly, privately, and with the highest medical standards.

Opening Hours:

Little Cross Family Clinic

Address: 929 Tampines Street 91, #01-445, Singapore 520929

Operating Hours:

Monday to Friday: 8:30 AM – 3:00 PM, 7:00 PM – 9:00 PM

Saturday: 8:30 AM – 12:30 PM, 7:00 PM – 9:00 PM

Sunday: Closed

Public Holidays: 8:30 AM – 12:30 PM

Phone / WhatsApp: +65 9711 3550

Anteh Dispensary

Address: 1 Lor 22 Geylang, #01-02, Singapore 398664

Operating Hours:

Monday to Friday: 9:00 AM – 12:00 PM, 2:00 PM – 5:00 PM, 7:00 PM – 11:00 PM

Saturday: 9:00 AM – 12:00 PM, 1:00 PM – 6:00 PM, 7:00 PM – 11:00 PM

Sunday / Public Holidays: 1:00 PM – 6:00 PM, 7:00 PM – 11:00 PM

Phone: +65 6744 1809

WhatsApp / Handphone: 8764 7488

FAQs

What is HIV Post Exposure Prophylaxis (PEP)?

HIV post exposure prophylaxis (HIV PEP) is an emergency antiretroviral treatment used to prevent contracting HIV after a high-risk exposure such as unprotected sexual intercourse, contaminated needles, or contact with infected genital fluids. It must be started as soon as possible—ideally within 72 hours—to reduce the risk of human immunodeficiency virus (HIV) infection.

Who should consider taking HIV PEP in Singapore?

HIV PEP Singapore is recommended for people with high-risk sexual exposure, including unprotected anal or vaginal intercourse, receptive oral intercourse, or contact with a HIV-positive individual. It’s also advised for IV drug users and healthcare workers with occupational exposures. Even if the partner’s known HIV status is uncertain, taking HIV PEP helps in preventing HIV transmission.

What tests are done before starting PEP?

Doctors perform a baseline HIV test, blood count, and STD screening to assess the patient’s risk and identify any pre-existing abnormality. These baseline blood tests help determine suitable HIV PEP treatment and monitor potential side effects when combined with other medications.

How long is the PEP course and what follow-up is needed?

The latest HIV PEP medications are taken for 28 days as part of antiretroviral therapy. A rapid test and follow-up HIV tests are repeated after the window period to ensure no HIV infection has developed. Follow-up includes STD tests and advice on safer practices for preventing HIV transmission.

Conclusion

Post-Exposure Prophylaxis is one of the most powerful tools in HIV prevention—but timing is everything. If you think you’ve been exposed to HIV, don’t wait or hesitate. Seek medical help immediately—preferably within the first 24 hours.

Singapore’s healthcare system provides discreet, professional, and accessible PEP services to anyone in need. Completing the full course, attending follow-ups, and practicing safe habits afterward are essential steps toward full protection and long-term health.

In short, PEP is your emergency shield against HIV—but it only works if you act fast, stay consistent, and follow through. Knowing your options and taking immediate action can make all the difference. Clinics like Little Cross Family Clinic and Anteh Dispensary Clinic provide timely, confidential PEP consultations to help you stay protected and supported when it matters most.