What You Need to Know About PEP for HIV Prevention

Chai C
Oct 9
3 min read

PEP for HIV prevention is a critical emergency treatment that can protect your health after potential exposure. While most people are familiar with condoms and pre-exposure prophylaxis (PrEP), fewer know about post-exposure prophylaxis (PEP)—a powerful emergency treatment that can prevent HIV infection if started soon after exposure. Understanding how PEP works, when to use it, and where to get it can help you take control of your health during high-stress situations.

What is PEP for HIV Prevention?

PEP stands for Post-Exposure Prophylaxis. It is a 28-day course of antiretroviral medication designed to prevent HIV from taking hold in the body after a potential exposure. It is an emergency prevention method and should not replace consistent HIV prevention strategies such as condom use or PrEP.According to the World Health Organization, timely PEP treatment is essential for HIV prevention.

How Does PEP Work?

PEP works by using antiretroviral drugs to stop HIV from replicating in the body before it establishes a permanent infection. It is most effective when started quickly and taken consistently for the full 28-day course.

For maximum effectiveness:

Start PEP as soon as possible, ideally within 2 hours of exposure and no later than 72 hours.
Take the medication exactly as prescribed without missing doses.
Attend follow-up testing to confirm HIV-negative status.

When Should You Consider PEP?

You should consider taking PEP if you have been exposed to HIV within the past 72 hours. Situations include:

Having unprotected sex with someone whose HIV status is unknown or positive.
Experiencing condom breakage during intercourse.
Sharing needles or syringes with someone who might be HIV-positive.
Suffering a needle-stick injury in a healthcare or work setting.
Being sexually assaulted.

If any of these scenarios occur, seek medical care immediately to discuss PEP.

Who Should Not Use PEP?

PEP is not appropriate if:

More than 72 hours have passed since the exposure.
The exposure did not involve HIV risk (e.g., casual contact or touching).
You are already on PrEP and have been taking it consistently.

In these cases, HIV testing and follow-up monitoring may be recommended instead.

How to Access PEP for HIV Prevention in Singapore

In Singapore, PEP is available at emergency departments, sexual health clinics, and family clinics. The typical process includes:

Consultation: A doctor assesses your risk of HIV exposure.
Testing: An HIV test confirms you are HIV-negative before starting PEP.
Prescription: You receive a 28-day supply of PEP medication.
Follow-Up: Return for HIV testing at 1, 3, and 6 months after exposure.

Read our step-by-step guide on where to get PEP in Singapore for more details.

What are the Side Effects of PEP?

PEP is generally well-tolerated but can cause mild side effects such as nausea, diarrhea, headache, or fatigue. These usually resolve over time. Your doctor can help manage any side effects if needed.

PEP vs. PrEP: What’s the Difference?

Although their names are similar, PEP and PrEP serve different purposes:

PEP: Taken after potential HIV exposure. Short-term (28 days).
PrEP: Taken daily before exposure for long-term prevention.

PEP is for emergencies, while PrEP is for ongoing protection for those at higher risk.

Why Acting Quickly is Crucial

HIV spreads rapidly in the body after exposure. PEP must begin within 72 hours to work effectively, and every hour matters. If you are unsure whether you need PEP, consult a doctor right away rather than delaying.

HIV Prevention Beyond PEP

While PEP is an essential emergency tool, it is not a replacement for other prevention strategies. Protect yourself further by:

Using condoms consistently and correctly.
Getting tested for HIV and STDs regularly.
Considering PrEP if you are at frequent risk.
Avoiding needle sharing.

By combining PEP education with these practices, you strengthen your overall HIV prevention strategy.

Conclusion: Protect Your Health Today

Understanding PEP for HIV prevention is crucial for responding quickly to possible HIV exposure. If you believe you’ve been exposed, act immediately—PEP is most effective within 72 hours.

For confidential consultations, timely treatment, and expert advice, visit:

📍 Location of Little Cross Family Clinic929 Tampines Street 91, #01-445, Singapore 520929🕒 Operating Hours:Monday to Friday: 8:30 AM – 3:00 PM, 7:00 PM – 9:00 PMSaturday: 8:30 AM – 12:30 PM, 7:00 PM – 9:00 PMSunday: Closed📞 Phone: +65 97113550

📍 Location of Anteh Dispensary1 Lor 22 Geylang, #01-02, Singapore 398664📞 Phone: +65 67441809📱 WhatsApp / Handphone: 87647488

Every hour counts. Visit these trusted clinics today for confidential care, HIV testing, and PEP guidance. Your health and peace of mind are worth it.